What is Androcur?
If you have been prescribed Androcur, it makes sense to get more information about the medicine first. In this article, we will tell you about this drug. .
The drug refers to a synthetic anti-androgens — antagonists of male sex hormones. It blocks the effect of androgens, which are also produced in small quantities in the body of women. It also has gestagenic and antigonadotropic effects. Cyproterone competitively blocks the effect of androgens on androgen-dependent organs, for example, by preventing the effect of androgens on the prostate gland. In men, when taking Androcur, a decrease in libido and potency as well as gonad function is observed. These changes disappear after stopping treatment. In women while taking Androcur the severity of hirsutism and androgen-dependent alopecia decreases, the hyperfunction of sebaceous glands decreases and the function of ovaries suppresses.
After oral administration, cyproterone acetate is completely absorbed in the digestive tract. Absolute bioavailability is about 88%. After oral administration of 50 mg of cyproterone acetate, maximum plasma concentration is observed after about 3 hours. It is metabolized by various pathways, including hydroxylation and conjugation. The main metabolite in blood plasma is the 15-hydroxy derivative. Some part of the dose taken is excreted unchanged in the bile. Cyproterone acetate is almost completely bound to plasma albumin, approximately 3.5-4% remains free. Since binding to proteins is non-specific, changes in the level of globulin that binds sex hormones have no effect on the pharmacokinetics of cyproterone acetate.
After the intravenous administration of the prolonged form of the drug, the maximum concentration of cyproterone acetate in blood plasma is observed after 2-3 days. During intravenous administration, the active substance is slowly released from the oil depot with a monophasic decrease in plasma concentrations and a half-life of about 4 days.
In men: anti-androgenic therapy in inoperable prostate cancer; pathological deviations of libido (when it is necessary to reduce sexual desire). In women: pronounced symptoms of androgenization (pronounced hirsutism), androgen-induced severe alopecia, which is often accompanied by severe forms of acne and/or seborrhea.
The use of Androcur decreases spermatogenesis in men, which recovers in a few months after stopping treatment. Very rarely, liver dysfunction, gynecomastia are observed, sometimes together with increased tactile sensitivity of the mammary glands nipples. In men during long-term treatment with Androcur, as well as during the use of other antiandrogenic drugs, the phenomenon of osteoporosis was observed in extremely rare cases. Rapid administration of Androcur can cause shortness of breath and cough.